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Research focus: (1) The YIA mechanism supports basic, translational and clinical research including but not limited to understanding cellular, genetic, and molecular mechanisms underlying the pathogenesis of NF, identifying novel therapeutic targets, testing candidate therapeutics, analysis of natural history of NF; (2) The focus of the YIA research may include but is not limited to NF1, NF2 or schwannomatosis; (3) The focus of the YIA research may include but is no limited to NF manifestations including neurofibromas, schwannomas, malignant peripheral nerve sheath tumors, brain and nervous system tumors, bone abnormalities, cardiovascular abnormalities, learning disorders and pain.