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Supports PD therapeutic development along the entire preclinical and clinical path. Although MJFF is open to any creative therapeutic strategy, ideal applications should focus on efforts to address one of the following treatment challenges: 1. Disease modifying strategies that protect or restore degenerating and/or dysfunctional neurons affected in PD (e.g., Protein folding, mitochondrial function, inflammation). 2. Strategies to alleviate disabling motor (both levodopa-responsive and non-levodopa-responsive, with particular focus on gait disorders and falls) and non-motor symptoms of PD (including cognitive dysfunction, mood disorders, autonomic dysfunction and sleep disorders). 3. Strategies to alleviate complications of PD treatment including dyskinesia, impulse-control disorders, and other disabling side effects.