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Teams should consist of a PI and at least one co-PI, possibly from different institutions. Teams consisting of both basic scientists and clinicians to address an unmet clinical need are encouraged, as is the inclusion of a junior scientist. All Team Awards must address one of the Specific Topic Proposals: (1) Prevention: Development of models and biomarkers; (2) Identifying mechanisms and respective therapeutic strategies in less common molecular subsets of melanoma; (3) Metastases: Dormancy and metastatic progression; (4) CNS Metastases: Development of markers of risk and rational therapeutic approaches; (5) Response to Treatment: Mechanisms and respective biomarkers for predicting response and for monitoring therapeutic response; (6) Resistance: Intrinsic/Innate/Primary resistance to immunotherapies in melanoma