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To foster novel scientific ideas, agents, targets, and technologies that have the potential to substantially advance the practice of clinical cancer research within the Group. The work proposed should use resources from completed SWOG trials or be directly translatable to future clinical trials in SWOG and the National Clinical Trials Network. These studies may involve scientific risk but potentially lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on cancer research.