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For the career development of individuals who wish to understand the cell and molecular mechanisms of altered human appearance or of therapeutic interventions. This award is intended to support research addressing human appearance issues caused by aging and/or environmental factors. Funding is available for research involving the cell and molecular mechanisms of human appearance including those mechanisms involved in hyper or hypo-pigmentation, aging, photoaging, or dry skin not related to disease or congenital defects. Funding can also be used to study cell and molecular mechanisms involved in therapeutic interventions such as non/minimally-invasive devices, peels, fillers, antioxidants, retinoids, and other topical and systemic agents.