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To support the new research in the areas of trauma, shock and sepsis to be performed by early scientists who wish to develop into outstanding independent investigators as part of their future career. The proposed research should focus on developing new knowledge related to the biology of trauma, shock and/or sepsis. Research may vary from basic cellular responses to clinical outcomes, and we encourage proposals that might include translational research and clinical application. Proposed research must have intrinsic importance, but may also contain a component for permitting the applicant to learn the methodology, theory, and conceptualizations necessary for developing into an outstanding independent researcher.