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Research projects must be clinical or translational in nature and must have direct applicability and relevance to sarcoma. Proposed research projects should be aimed toward developing personalized, therapeutic options for the treatment of sarcoma patients. Investigators utilizing novel experimental tools and techniques geared toward better understanding sarcoma in an effort to elucidate the mechanisms of currently available therapies, and/or to identify new therapeutic targets are encouraged to apply. Emphasis will be placed on proposals involving research with immediate clinical applications, including those with predictive biomarker studies.