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For research proposals which specifically address any of the objectives listed below: a. Explore early mechanisms of disease in Huntington disease through unbiased analysis of genetically defined tissues or cells with a goal of uncovering or sharing the discovery of new pathways or processes affected in HD; b. Elucidate the normal biological functions of the huntingtin protein, with experiments involving either endogenous normal huntingtin or huntingtin protein in a full-length context;

c. Further the understanding of the impact on HD of increasing numbers of alleles or repeats and the CAG DNA expansion process;

d. Further the analysis of modifier genes to determine the impact on various aspects of HD.