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To support individual scientists with a trajectory of success, who propose novel approaches to major research challenges in the areas of CV and stroke that have the potential to produce unusually high impact. This competition will enable AHA to further develop and strengthen the community of CV and stroke researchers and bring innovative approaches to basic, clinical, population and translational studies through funding a variety of disciplines. Applications are encouraged from all basic disciplines as well as epidemiological, behavioral, community and clinical investigations that bear on cardiovascular and stroke problems.