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Any study that focuses on the pathogenesis of FD/MAS or clinical investigative studies to address any of the unmet needs in FD/MAS patients and their management will be considered. Research priorities for the Fibrous Dysplasia Foundation (FDF) include: studies that characterize mouse models; studies to understand the mechanism and/or treatment of FDrelated bone pain; development/testing of therapeutics, especially those targeting GsĪ±, PKA or
Wnt signaling pathways; studies of the molecular etiology, especially the role of RANKL, IL6, cAMP and FGF23. Projects that feature collaborations across multiple institutions are encouraged.