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To perform further investigation and
functional characterizations of candidate pathological genomic aberration(s) identified in unicentric Castleman disease (UCD) or HHV-8-negative/”idiopathic” multicentric Castleman disease (iMCD), such as PDGFRb. Proposals should seek to validate identified candidate genomic aberrations through functional assays to clearly demonstrate an effect of the identified aberration. We expect the investigator’s application to provide information on the genomic aberration identified, functional studies to demonstrate the effect of the aberration and hypothesized mechanisms for how the aberration leads to UCD or iMCD pathogenesis.
Proposing pharmacologic studies to revert the phenotype is a plus.