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To study the comparative effectiveness of alternate features of healthcare systems (e.g., innovative technologies, incentive structures, service designs) intended to optimize the quality, outcomes, and/or efficiency of care for the patients they serve and that have the most potential for sustained impact and replication within and across healthcare systems. PCORI seeks to fund studies that will provide information of value to patients, their caregivers, clinicians, and healthcare leaders regarding which features of delivery systems lead to better patient-centered outcomes so they may ultimately impact healthcare delivery.