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To fund innovative research awards that are patient-oriented. For the purposes of these awards, patient-oriented research is defined as: (1) research conducted with human subjects; (2) research on new diagnostic and therapeutic interventions; and (3) research on material of human origin such as tissues and specimens. While research that explores mechanisms of human disease is highly encouraged, the research projects should be translational in nature; i.e., have direct applicability to clinical care. In general, studies involving animals will not be considered unless the work cannot be done in humans.