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To answer questions that are of strategic importance for scientific progress in three broad areas heart failure. See RFP for specific questions. This grant mechanism is part of the AHA’s CVGPS Program that aims to combine the power of long-term population studies with the precision of molecular analyses in order to unravel key distinctions between and within subgroups of cardiovascular disease or stroke patients. The discoveries it generates will point the way toward better-targeted, safer and more effective treatments, based on a deeper understanding of patients’ characteristics.